Spectrum Of Activity
Oral: 500 -1000 mg TID
Following IV ampicillin and erythromycin x 48 hOral: 250 mg TID x 5 days (in combination with oral erythromycin)
Shake bottle well before using
5 to 20 mg/kg/day PO given as a single daily dose or in divided doses Q12H
Reconstitution instructions for 250 mg/5 mL powder for oral suspension:
1. Shake bottle to loosen powder
2. Add 68mL of sterile water to the bottle to make a total volume of 100mL
3. Shake bottle well
50 mg/mL = 14 daysRefrigerate
Therapy of Streptococcal, Enterococcal infections as well as susceptible gram negative infections.
Commonly used for respiratory tract infections and urinary tract infections.
Used as part of the preterm prelabour rupture of membranes (PPROM) protocol after 48 h of IV ampicillin and erythromycin administration.
Gastrointestinal side effects
Allergy/rash (immediate or delayed), cytopenias
- Note EBV related rash
Contraindicated in patients with true penicillin allergies.
Amoxicillin shares a common structural side chain with cephalexin, therefore, there is an increased risk of allergy cross reactivity between these agents.
- Please see penicillin and beta lactam allergy management document and cross reactivity table.
Antimicrobial class: Aminopenicillin