Antimicrobials
Valacyclovir

Valacyclovir

None
Excellent

Spectrum of Activity

Dosing

General Information

Pregnancy: Compatible.

Breastfeeding: Compatible.

Treatment and prevention of infections caused by HSV (genital, orolabial), VZV

CBC, Scr, liver enzymes

Headache GI intolerance Increased liver enzymes Thrombocytopenia, leukopenia Rash

May increase the serum concentration of clozapine, tenofovir. May diminish the therapeutic effect of Varicella Virus Vaccine. Management: When possible, avoid use of acyclovir or valacyclovir within the 24 hours prior to administration of the varicella vaccine, and avoid use of these antiviral agents for 14 days after vaccination.

Pro-drug of acyclovir. Valacyclovir is rapidly and nearly completely converted to acyclovir by intestinal and hepatic metabolism.

Antimicrobial class: Antiviral.