Voriconazole - Renal Dosing

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

0 - 50 eGFR

IV formulation not recommended due to accumulation of vehicle (cyclodextrin), switch to oral. No dose modification needed.

50+ eGFR

No dose adjustment required.