Nocardia sp

General Information

  • Cotrimoxazole (trimethoprim-sulfamethoxazole)

  • Imipenem + Cotrimoxazole (trimethoprim-sulfamethoxazole) (CNS infections)

  • Linezolid (prolonged treatment associated with neuropathies)

  • Branched, filamentous, Gram positive bacteria; order Actinomycetales

  • First described by Edmond Nocard in 1888

  • 100 species (N. brasiliensis, N. farcinica,...)

  • Saprophyte in the environment (water, dust, earth,...)

  • Infections in immunosuppressed patients (solid organ or hematopoietic stem cell transplant) but approximately 1/3 of infections occur in immunocompetent patients

All organs can be affected

  • Cutaneous infections

  • CNS infection

  • Pulmonary infections