Salmonella typhi

General Information

Aerobic gram negative rod

Humans are the reservoir - fecal-oral transmission.

Increased prevalence in developing countries.

Highest prevalence South Asia.

  • Fever in Returning Traveler

  • Enteric fever

  • FUO

  • Bacteremia

  • Intra-abdominal abscess

  • Meningitis

  • Endovascular infection including endocarditis and infected atherosclerotic plaque/aneurysm - "sticky" organism

Very high rates of FQ resistance in Indian Subcontinent.

Vaccination only prevents ~75% of disease.

Chronic carriage associated with gallbladder disease.